Arsenal 1 Liverpool 1: Liverpool secured an all-important away goal in a thrilling Champions League quarter-final first leg match at the Emirates Stadium.
The Gunners, who have seen their Premier League title hopes fade following a run of just one win in six, had taken an early lead through Emmanuel Adebayor.
However, the Reds, last season's beaten finalists, hit back quickly through Dirk Kuyt's close-range effort after a fine run from captain Steven Gerrard.
Arsenal dominated the second half and should have had a penalty when Alexander Hleb was clearly tugged back by Kuyt. However, Arsene Wenger's men could not find a way past Liverpool who will now fancy their chances of securing another European Cup semi-final appearance when the two sides meet again at Anfield next Tuesday night.
Despite the electric atmosphere, it was a cagey opening for what was the 200th meeting of the sides, who will face off once more in the Premier League on Saturday lunchtime.
On 21 minutes, the Liverpool defence was split by a fine chipped pass from Mathieu Flamini. Robin van Persie got ahead of the two centre-backs and into the penalty area, but as the ball dropped, the Dutchman could only fire a left-footed volley over the crossbar.
Reina then had to get down quickly to deny the Arsenal striker, who sent in a low shot from the edge of the box. From the resulting corner, after 22 minutes, the Gunners took the lead.
Van Persie knocked the ball short to Fabregas before he whipped it into the area, where Adebayor leapt highest to nod his first goal since scoring in the defeat of AC Milan at the San Siro.
However, Arsenal's lead was short-lived as the visitors grabbed what could yet prove to be a crucial away goal in the 26th minute. Gerrard powered into the left side of the penalty box, charging past three defenders.
The Liverpool skipper kept his feet to send over a low cross, which Kuyt bundled in ahead of full-back Gael Clichy.
The visitors were clearly lifted by their goal and enjoyed a decent spell of possession as the half-hour mark passed. However, despite plenty of action around both penalty areas, neither side was able to find a penetrating pass.
Arsenal introduced England squad man Theo Walcott, to replace van Persie, for the second half and the teenager looked lively down the left as Hleb was given more freedom in an advanced role.
Walcott picked up the ball and let fly from 25 yards, but his shot was always going wide of Reina's right-hand post.
Again both teams were not scared of going forwards, however once more they lacked a decisive pass in the final third.
On 65 minutes, there was a double let-off for Liverpool when Martin Skrtel blocked Emmanuel Eboue's effort before Arsenal had what looked a certain penalty turned down by the Dutch referee.
Hleb weaved into the box, before he clearly had his shirt tugged back by Kuyt. However, referee Pieter Vink was unconvinced and signalled instead only for a corner.
Wenger sent on Nicklas Bendtner for the final 24 minutes, replacing Eboue as Walcott moved out to the right and Hleb to the left. The Danish striker was soon in the thick of the action, somehow managing to keep out Fabregas' goalbound effort while on the line — although he was flagged offside.
Arsenal continued to press in the closing stages, and in stoppage time Fabregas dived in to meet Adebayor's cross, but his header lacked power and Reina comfortably collected.
Liverpool — with 10 men behind the ball for long spells — held firm and take the upper hand into next week's second leg at Anfield.