Ben Foster is likely to keep his place in the Manchester United goal when Alex Ferguson's side take on Bolton, while Chelsea's Petr Cech could make return to action against Tottenham.
Edwin van der Sar's groin problem is set to keep him out of the United team again and although Tomasz Kuszczak is available after serving a one-match ban, Foster's excellent performance on his debut against Derby may persuade Ferguson to keep faith with the 24-year-old tomorrow.
Cech, meanwhile, has virtually recovered from his ankle problem and should be included in the squad for Wednesday's game.
Chelsea have no fresh injury worries but coach Avram Grant must decide whether to choose Nicolas Anelka or Didier Drogba to lead the attack.
Republic of Ireland captain Robbie Keane could pay for his petulant outburst when being substituted in the defeat to Manchester City at the weekend.
Keane was clearly annoyed by coach Juande Ramos' decision and it remains to be seen whether the Spaniard opts for Darren Bent for the visit of Chelsea instead.
Spurs need to check on Ledley King's calf injury ahead of the match at White Hart Lane, while Ricardo Rocha (groin) has been struggling.
Fellow defender Younes Kaboul (knee), however, is back in contention.
Gareth Bale (foot) and Benoit Assou-Ekotto (knee) are out of the season.
Provisional Man United squad: Foster, Kuszczak, Brown, Vidic, Ferdinand, Evra, Ronaldo, Carrick, Fletcher, Hargreaves, Nani, Rooney, Tevez, Scholes, Giggs, O'Shea, Saha, Anderson, Park, Pique, Heaton.
Provisional Chelsea squad: Cech, Cudicini, Hilario, Ferreira, Belletti, Carvalho, Alex, Ben-Haim, Terry, A Cole, Bridge, Ballack, Lampard, Essien, Mikel, Lampard, Shevchenko, Pizarro, Sidwell, Wright-Phillips, Malouda, Drogba, Anelka, Kalou, Makelele.
Provisional Tottenham squad: Robinson, Cerny, Chimbonda, Hutton, Lee, Gilberto, Gunter, Woodgate, King, Kaboul, Dawson, Zokora, Tainio, Jenas, Malbranque, Lennon, Huddlestone, O'Hara, Boateng, Taarabt, Berbatov, Keane, Bent.
