Saturday (3pm unless stated)
Everton (16) v Aston Villa (13), 12.30pm – Live on BT Sport 1
Everton caretaker manager Duncan Ferguson has promised changes as he bids to turn around a run of one win in 13 matches which led to Rafael Benitez's sacking. Fabian Delph is the Toffees' only short-term absentee, with fellow midfielder Tom Davies out until March after a knee operation.
Villa have John McGinn available after suspension and Lucas Digne makes a swift return to Everton following his move to Villa this month. Ezri Konsa is a doubt with a hip injury while Trezeguet is on international duty with Egypt and Leon Bailey (hamstring) and Marvelous Nakamba (knee) are out.
Last season: Aston Villa 0 Everton 0, Everton 1 Aston Villa 2
Last five league matches: Everton W L D L L; Aston Villa L W L L D
Top scorers (all competitions): Demarai Gray & Andros Townsend (Everton) 6; Ollie Watkins (Aston Villa) 5
Match odds: H 17-10 A 13-8 D 11-5
Referee: Craig Pawson
Brentford (14) v Wolves (8)
Brentford will have an unchanged squad. Midfielder Josh Dasilva has made a welcome return to training for the first time this season following a hip injury, but he is still around four weeks from being available. Charlie Goode, David Raya and Julian Jeanvier remain on the sidelines.
Ruben Neves and Ki-Jana Hoever are back in contention for Wolves after Covid-19 isolation. Jonny Castro Otto, Pedro Neto (both knee), Willy Boly (calf), Hwang Hee-chan and Yerson Mosquera (both hamstring) remain unavailable and defender Romain Saiss is still with Morocco at the Africa Cup of Nations.
Last season: No corresponding fixture
Last five league matches: Brentford L W L L L; Wolves L W D W W
Top scorers (all competitions): Bryan Mbeumo (Brentford) 7; Chiquinho, Hwang Hee-Chan, Raul Jimenez & Daniel Podence (Wolves) 4
Match odds: H 21-10 A 6-4 D 2-1
Referee: Peter Banks
Leeds (15) v Newcastle (19)
Leeds striker Patrick Bamford has sustained a foot issue but defender Diego Llorente is available after suspension. Forwards Joe Gelhardt (ankle) and Tyler Roberts (calf) could return to contention – Roberts was also suspended last week – but Adam Forshaw and Junior Firpo (both hamstring) are out.
Newcastle will assess wing back Matt Richie (knee). Midfielder Jeff Hendrick and striker Dwight Gayle have returned to training and Javier Manquillo is available following a one-match ban but Federico Fernandez (thigh), Isaac Hayden (knee) and Callum Wilson (calf) are still out.
Last season: Newcastle 1 Leeds 2, Leeds 5 Newcastle 2
Last five league matches: Leeds L L L W W; Newcastle L L L D D
Top scorers (all competitions): Raphinha (Leeds) 8; Callum Wilson (Newcastle) 6
Match odds: H 1-1 A 13-5 D 13-5
Referee: Chris Kavanagh
Manchester United (7) v West Ham (4) – Live on Premier Sports 2
Central defender Victor Lindelof is absent for United as he supports his family following a break-in. Captain Harry Maguire is the obvious choice to replace Lindelof in a defence that will again be without Luke Shaw and Aaron Wan-Bissaka. Jadon Sancho is a doubt following the death of a relative.
West Ham will check on Tomas Soucek and Kurt Zouma – midfielder Soucek is back after a positive Covid-19 test and centre half Zouma is recovering from a hamstring injury. Winger Said Benrahma is not expected back from the Africa Cup of Nations in time.
Last season: Man Utd 1 West Ham 0, West Ham 1 Man Utd 3
Last five league matches: Man Utd D W L D W; West Ham L W W W L
Top scorers (all competitions): Cristiano Ronaldo (Man Utd) 14; Michail Antonio & Jarrod Bowen (West Ham) 9
Match odds: H 10-11 A 11-4 D 27-10
Referee: Jon Moss
Southampton (12) v Manchster City (1), 5.30pm – Live on Sky Sports Premier League and Main Event
Theo Walcott and Mohamed Elyounoussi are in contention for Southampton following absences due to Covid-19. Goalkeeper Alex McCarthy (hamstring), right back Tino Livramento (knee) and midfielder Will Smallbone (calf) are sidelined and Mali winger Moussa Djenepo is at the Africa Cup of Nations.
City are not rushing Riyad Mahrez back into action following Algeria’s early elimination from the tournament in Cameroon – Mahrez is to be given a week off and will return for City after the winter break. Centre back Nathan Ake is available after a knock but left back Oleksandr Zinchenko is still sidelined.
Last season: Man City 5 Southampton 2, Southampton 0 Man City 1
Last five league matches: Southampton D W D W L; Man City W W W W W
Top scorers (all competitions): Armando Broja (Southampton) 7; Riyad Mahrez (Man City) 13
Match odds: H 9-1 A 2-7 D 9-2
Referee: Simon Hooper
Sunday (2pm unless stated)
Arsenal (6) v Burnley (20)
Midfielders Granit Xhaka and Thomas Partey are banned and Pierre-Emerick Aubameyang's involvement is in doubt. Calum Chambers (neck), Cedric Soares (hip) and Bernd Leno (back) missed Arsenal's Carabao Cup loss to Liverpool and Mohamed Elneny and Nicolas Pepe are at the Africa Cup of Nations.
Burnley still face uncertainty over which players might be available following a Covid-19 outbreak. Ashley Barnes remains out with injury, Charlie Taylor is doubtful and although Sean Dyche has said Matej Vydra is available, the striker is dealing with a hernia problem which may require surgery.
Last season: Burnley 1 Arsenal 1, Arsenal 0 Burnley 1
Last five league matches: Arsenal W W W W L; Burnley D L D L L
Top scorers (all competitions): Emile Smith Rowe (Arsenal) 9; Maxwel Cornet (Burnley) 6
Match odds: H 4-11 A 17-2 D 7-2
Referee: David Coote
Crystal Palace (11) v Liverpool (2) – Live on Sky Sports Premier League and Main Event
Boss Patrick Vieira says Jordan Ayew, who returned from the Africa Cup of Nations this week following a shock early exit for Ghana, is in Palace's squad. Cheikhou Kouyate and Wilfried Zaha remain in Cameroon on international duty for the tournament while James McArthur and James Tomkins are injured.
Forward Alex Oxlade-Chamberlain could return to the Liverpool squad after a twisted ankle. Midfielder Fabinho is expected to shake off the effects of a heavy tackle in the Carabao Cup win at Arsenal but forward Harvey Elliott (ankle) will not be in contention until after the international break.
Last season: Liverpool 2 Crystal Palace 0, Crystal Palace 0 Liverpool 7
Last five league matches: Crystal Palace D L W L D; Liverpool W D L D W
Top scorers (all competitions): Odsonne Edouard (Crystal Palace) 8; Mohamed Salah (Liverpool) 23
Match odds: H 5-1 A 11-20 D 3-1
Referee: Kevin Friend
Leicester (10) v Brighton (9)
Kiernan Dewsbury-Hall (calf) is available for Leicester and Daniel Amartey is back after Africa Nations Cup action. However, Jamie Vardy, Jonny Evans, Wesley Fofana, Timothy Castagne and Ricardo Pereira are injured and Wilfred Ndidi, Kelechi Iheanacho and Nampalys Mendy are on international duty.
With boss Graham Potter having tested positive for coronavirus, assistant Billy Reid will take charge for Brighton. Lewis Dunk could be back in contention after a knee injury but Shane Duffy (ankle) and Adam Lallana (hamstring) are unavailable and Yves Bissouma is still at the Africa Cup of Nations.
Last season: Brighton 1 Leicester 2, Leicester 3 Brighton 0
Last five league matches: Leicester L W L W L; Brighton W D W D D
Top scorers (all competitions): Jamie Vardy (Leicester) 11; Neal Maupay (Brighton) 8
Match odds: H 6-4 A 9-5 D 9-4
Referee: Martin Atkinson
Chelsea (3) v Tottenham (5), 4.30 – Live on Sky Sports Premier League and Main Event
Chelsea defender Andreas Christensen will miss out due to continued Covid-19 isolation. Trevoh Chalobah (thigh) and Reece James (hamstring) are on the comeback trail but will not feature against Spurs.
Spurs have Eric Dier available after injury. Son Heung-min (muscle) is still out and although Cristian Romero could return, boss Antonio Conte said a couple of players picked up issues in the win at Leicester – one is Emerson Royal.
Last season: Tottenham 0 Chelsea 1, Chelsea 0 Tottenham 0
Last five league matches: Chelsea W D D L D; Tottenham D W D W W
Top scorers (all competitions): Jorginho (Chelsea) 9; Harry Kane (Tottenham) 11
Match odds: H 13-20 A 9-2 D 27-10
Referee: Paul Tierney
