Carling Cup review:A man was stabbed and violent battles broke out between rival football fans in "large-scale" crowd trouble at the Carling Cup tie between West Ham and Milwall at Upton Park.
Hundreds of fans were involved in the disorder which police said was caused by people without tickets to the game who had planned to start trouble.
A spokesman for Metropolitan Police said more officers were being rushed to the scene outside Upton Park, in east London.
"There is large-scale trouble involving hundreds of fans which we are dealing with at the moment," he added.
Officers have made two arrests, one for disorder and the second for breach of a banning order.
Police said the stabbing, in Priory Road close to the stadium, is connected to the fighting and the man is being treated by paramedics.
Inside the stadium the game went to extra-time after a 1-1 draw in 90 minutes.
After Junior Stanislas's second goal gave West Ham the lead from the penalty spot in extra-time, fans invaded the pitch and the game was disrupted further.
Order was restored and the Hammers sealed the win with through a goal from Zavon Hines but outside police were said to be 'containing' violent clashes.
On a night devoid of top-flight casualties Mick McCarthy's Wolves came closest to a surprise exit as they were pushed to a penalty shoot-out after 120 minutes of stalemate against Swindon at Molineux.
However after 11 successful penalties in succession the heartbreak fell to the League One side's Gordon Greer who struck the left upright, giving Wolves a narrow 6-5 win from the spot.
Burnley might be basking in their stunning Barclays Premier League start but they were fortunate to avoid a giant-killing themselves after being pushed to extra-time at Hartlepool.
Adam Boyd gave the hosts the half-time advantage and the lead lasted until six minutes from time when Steven Fletcher scored from close-range. Fletcher grabbed his second in extra-time after Richard Eckersley was sent off.
Alex McLeish's Birmingham survived a similar scare at the St Mary's Stadium as Southampton, bottom of League One, grabbed a 50th-minute lead through Adam Lallana.
The Saints deserved to go ahead after dominating for long periods but McLeish's men hit back through Lee Bowyer on 77 minutes. Lee Carsley hit the Blues winner three minutes later.
Bolton were also fortunate to avoid extra-time against Tranmere at Prenton Park, with Mark Davies grabbing the only goal of the game in the 41st minute when his long-range effort squeezed through keeper Luke Daniels' hands.
David Hoilett scored on his full debut for Blackburn and David Dunn and Morten Gamst Pedersen also found the net as Sam Allardyces men earned a 3-1 win at Gillingham.
Frederic Piquionne, John Utaka, Niko Kranjcar and Richard Hughes were all on the scoresheet in Portsmouth's 4-1 win over Hereford, for whom Tristan Plummer scored a late consolation from the spot.
There was a similar stroll for Hull who beat Southend 3-1 at the KC Stadium. Tom Cairney and Jozy Altidore put the Tigers in front and although Franck Moussa reduced the deficit Geovanni sealed the win in the second half.
Robert Snodgrass scored a double including an extra-time winner as League One Leeds pulled off a minor upset with a 2-1 win over Watford at Elland Road.
Radoslaw Majewski's extra-time winner gave Nottingham Forest a 2-1 win over Middlesbrough at the City Ground while Roy Keane's tough start to the season at Ipswich continued with a 2-1 defeat at Peterborough.
