Today
Blackburn v Derby
Blackburn's record signing, Kevin Davies, is set to line up alongside Chris Sutton. Darren Peacock and French midfielder Sebastien Perez are also poised for debuts. Jimmy Corbett, Tore Pedersen and Marlon Broomes are injured and England keeper Tim Flowers is suspended with Australian John Filan deputising.
Argentine defender Horacio Carbonari is in line for his Premiership debut for Derby after recovering from a groin injury. New signing, defender Stefan Schnoor, is also likely to play. Stefan Eranio and Igor Stimac, who both have minor knee injuries, face late fitness tests.
Last season: Blackburn 1 Derby 0, Derby 3 Blackburn 1
Match odds: H 8-11 A 100-3 D 9-4
Referee: S Lodge (Barnsley)
Coventry v Chelsea
Dion Dublin was injured against Espanol last weekend and David Burrows missed the match with a minor knee injury but the pair have been passed fit to play for Coventry. Philippe Clement is ruled out with a fractured cheekbone.
Danish striker Brian Laudrup is Chelsea's only doubt but may be fit to make his debut along with the club's three other summer signings - Marcel Desailly, Pierluigi Casiraghi and Albert Ferrer.
Last season: Coventry 3 Chelsea 2, Chelsea 3 Coventry 1
Match odds: H 9-4 A 6-5 D 15-8
Referee: G Barber (Pyrford, Surrey)
Everton v Aston Villa
Slaven Bilic (groin injury) is the only doubt for new Everton boss Walter Smith as he approaches his first game in the Premiership. New signings Alex Cleland, John Collins, Olivier Dacourt and Marco Materazzi are expected to make their debuts, and Scottish striker John Spencer will partner Duncan Ferguson up front.
Dwight Yorke will spearhead Villa's attack in the opening game of the season at Everton tomorrow. He will be joined in attack by Julian Joachim as £7million striker Stan Collymore is sidelined by a thigh strain.
Last season: Everton 1 Aston Villa 4, Aston Villa 2 Everton 1
Match odds: H 11-8 A 13-8 D 11-5
Referee: A Wilkie (Chester-le-Street)
Man Utd v Leicester
United boss Alex Ferguson gives new signing Jaap Stam his Premiership debut. Stam's fellow new recruit Jesper Blomqvist is sidelined by a heel injury. Roy Keane will lead the side in a Premiership game for the first time since September 27th.
Record £2 million signing Frank Sinclair goes straight into Leicester's starting line.
Last season: Man Utd 0 Leicester 1, Leicester 0 Man Utd 0
Match odds: H 4-11 A 8-1 D 11-4
Referee: N Barry (Scunthorpe)
Middlesbrough v Leeds
Middlesbrough have fitness doubts over goalkeeper Mark Schwarzer, central defenders Gary Pallister and Gianluca Festa, and Paul Gascoigne. Central defender Steve Vickers is suspended while strikers Marco Branca and Alun Armstrong are ruled out through injury.
Leeds will be without last season's 22goal leading scorer Jimmy Floyd Hasselbaink, who is suspended, and defenders Gunnar Halle and Mark Jackson also serve one-match bans. Gary Kelly and Alan Maybury are both sidelined with shin injuries, and David Robertson is also out with a knee problem.
Last season: No corresponding fixtures
Match odds: H 11-8 A 13-8 D 11-5
Referee: D Elleray (Harrow-on-the-Hill)
Newcastle v Charlton
Kenny Dalglish is expected to give German World Cup star Dietmar Hamann a Premiership debut for Newcastle. But French World Cup winner Stephane Guivarc'h has not fully recovered from a twisted ankle.
Clive Mendonca has shaken off a back injury and will lead the Charlton line. Welsh international defender Mark Bowen misses the trip north because of a groin injury he picked up in a friendly at Welwyn on Monday.
Last season: No corresponding fixtures
Match odds: H 8-15 A 5-1 D 12-5
Referee: D Gallagher (Banbury, Oxfordshire)
Sheff Wed v West Ham
Wednesday boss Danny Wilson looks certain to hand debuts to summer signings Wim Jonk and Juan Cobian. Wilson, however, is without Ian Nolan (broken leg), Jon Newsome (ankle), Goce Sedloski (broken nose), Niclas Alexandersson (knee), while Dejan Stefanovic is still fighting to get a new work permit. Skipper Peter Atherton will play, after a quick recovery this week from a slight strain of mumps.
West Ham have John Hartson suspended so Ian Wright will partner Trevor Sinclair up front. Ludek Miklosko (calf strain) and Lee Hodges (illness) are out but Tim Breacker is included in the squad. ebuts.
Last season: Sheff Wed 1 West Ham 1, West Ham 1 Sheff Wed 0
Match odds: H 11-8 A 13-8 D 11-5
Referee: P Durkin (Portland, Dorset)
Wimbledon v Tottenham
Wimbledon manager Joe Kinnear has failed to add to his squad during the summer and is without defenders Ben Thatcher, who is suspended, and knee injury victim Brian McAllister.
Spurs boss Christian Gross has striker Steffen Iversen, winger Andy Sinton and defender John Scales ruled out by injuries. Les Ferdinand and Chris Armstrong will lead the attack and new £1.5 million Italian signing Paolo Tramezzani makes his debut at left back.
Last season: Wimbledon 2 Tottenham 6, Tottenham 0 Wimbledon 0
Match odds: H 6-4 A 6-4 D 11-5
Referee: G Poll (Tring, Hertfordshire)
Sunday
Southampton v Liverpool
New signings Mark Hughes and Stuart Ripley are both poised to make their Southampton debuts. Midfielder David Howells is also in contention for a first start at The Dell. But defender Francis Benali is beginning a four-match ban, while striker David Hirst is out until the start of next month with a knee injury.
Skipper Paul Ince (groin), plus new signings Steve Staunton (toe) and Vegard Heggem (back) are all expected to recover from injuries to be fit for Liverpool. Czech Patrik Berger could form a strike pairing with Michael Owen, while Jason McAteer is tipped to play in midfield. American keeper Brad Friedel will keep out David James.
Last season: Southampton 1 Liverpool 1, Liverpool 2 Southampton 3
Match odds: H 9-4 A 6-5 D 15-8
Referee: M Reed (Birmingham)
