Saturday
Chelsea (9) v Ipswich (4)
Carlo Cudicini is expected to continue in goal for the home side. Frank Leboeuf could lose his place in central defence to a fit-again Mario Melchiot, while Celestine Babayaro, Graeme Le Saux, Albert Ferrer and Jesper Gronkjaer are all in contention.
Ipswich will be without the suspended Titus Bramble but Mark Venus is set to return after missing the 2-0 defeat of Leicester with a bruised thigh.
Last season: No corresponding fixture.
Last five league matches: Chelsea L W D W D, Ipswich L D W L W.
Top scorers: Jimmy Floyd Hasselbaink (Chelsea) 15; Marcus Stewart (Ipswich) 16.
Match odds: H 4/7; A 4/1; D 5/2.
Referee: A D'Urso (Essex).
Coventry (18) v Everton (16)
Paul Williams and record £6.5 million signing Craig Bellamy are suspended, but Moroccan midfield duo Youssef Chippo and Moustapha Hadji are back from international duty.
With 11 players out injured and three suspended, Everton boss Walter Smith has only 11 senior players fit.
Last season: Coventry 1 Everton 0, Everton 1 Coventry 1.
Last five league matches: Coventry D W D D L, Everton D L L L D.
Top scorers: John Aloisi and Craig Bellamy (Coventry) 6, Francis Jeffers (Everton) 7.
Match odds: H 11/10; A 2/1; D 11/5.
Referee: P Durkin (Dorset).
Derby (17) v Manchester City (19)
Branko Strupar and Giorgi Kinkladze are both out with groin injuries while Stefano Eranio is suspended. Defender Taribo West returns from international duty with Nigeria.
Darren Huckerby (ankle) and Jeff Whitley (hip) are doubtful for City but Gerard Wiekens is expected to return from his hamstring injury.
Last season: No corresponding fixture.
Last five league matches: Derby W D L W L, Man City L D L D L.
Top scorers: Malcolm Christie (Derby) 10, Paulo Wanchope (Man City) 12.
Match odds: H 4/5; A 11/4; D 23/10.
Referee: J Winter (Stockton-on-Tees).
Leeds (12) v Newcastle (7)
Rio Ferdinand is fit and Robbie Keane is likely to start up front. Gary Kelly is available after missing the last two games but Harry Kewell remains sidelined with David O'Leary revealing he could be out for another month at least.
For Newcastle, Gary Speed will undergo a late fitness test and Rob Lee, Wayne Quinn and Nolberto Solano are back in the squad - but Kieron Dyer serves out the second of a two-match ban.
Last season: Newcastle 2 Leeds 2, Leeds 3 Newcastle 2.
Last five league matches: Leeds W L L D W, Newcastle L W D L W.
Top scorers: Mark Viduka (Leeds) 14, Alan Shearer (Newcastle) 7,
Match odds: H 4/6; A 10/3; D 12/5.
Referee: A Wiley (Staffs).
Leicester (6) v Arsenal (3)
Leicester boss Peter Taylor includes new signings Roberto Mancini and Dean Sturridge in his 16. Gerry Taggart is poised to return after injury but Tim Flowers, Darren Eadie and Stefan Oakes are still sidelined.
Arsenal have £6 million Brazilian newcomer Edu in their squad. Skipper Tony Adams and Dutch striker Dennis Bergkamp are fit again and David Seaman looks certain to retain his place in goal - but Gilles Grimandi, Kanu and Lauren will not feature due to injuries.
Last season: Leicester 0 Arsenal 3, Arsenal 2 Leicester 1.
Last five league matches: Leicester W W L L L, Arsenal L W D L D.
Top scorers: Muzzy Izzet (Leicester) 7, Thierry Henry (Arsenal) 14.
Match odds: H 11/5; A evens; D 11/5.
Referee: B Knight (Kent).
Liverpool (5) v Middlesbrough (15)
New signing Jari Litmanen is expected to make his home debut for Liverpool but Christian Ziege and Djimi Traore are still injured.
With Hamilton Ricard suspended and Republic of Ireland wing-back Keith O'Neill out with a groin injury, Brian Deane or Noel Whelan will take over from Ricard, while Dean Gordon will replace O'Neill.
Last season: Liverpool 0 Middlesbrough 0, Middlesbrough 1 Liverpool 0.
Last five league matches: Liverpool W W L W W, Middlesbrough D W D D W.
Top scorers: Emile Heskey (Liverpool) 15, Alen Boksic (Middlesbrough) 10.
Match odds: H 2/5; A 13/2; D 13/5.
Referee: S Dunn (Bristol).
Manchester Utd (1) v Aston Villa (13)
Alex Ferguson is set to make changes with Andy Cole and Jaap Stam ready to start their first home game in months. Nicky Butt should also be in the squad. Cole, Teddy Sheringham, Ole Gunnar Solskjaer and Dwight Yorke all compete for places up front. Paul Scholes is still ruled out by a rib injury.
Villa hope to hand a debut to new £9.5 million record signing Juan Pablo Angel. Gareth Southgate is out with damaged knee ligaments.
Last season: Aston Villa 0 Man Utd 1, Man Utd 3 Aston Villa 0.
Last five league matches: Man Utd W W D W W, Aston Villa D W L L L.
Top scorers: Teddy Sheringham (Man Utd) 17, Dion Dublin (Aston Villa) 5.
Match Odds: H 2/7; A 15/2; D 10/3.
Referee: M Riley (Leeds).
Tottenham (10) v Southampton (14)
Ian Walker gets a rare start for Spurs at home to Southampton in place of suspended goalkeeper Neil Sullivan. Tim Sherwood is also suspended.
Latvian striker Marian Pahars (calf) is struggling to recover from injury. Midfielder Chris Marsden is also a doubt, but Moroccan defender Tahar El Khalej is available again after international duty.
Last season: Tottenham 7 Southampton 2, Southampton 0 Tottenham 1.
Last five league matches: Tottenham D L L W D, Southampton D W W L D.
Top scorers: Steven Ferguson (Tottenham) 9, James Beattie (Southampton) 10.
Match odds: H 4/7; A 4/1; D 5/2.
Referee: C Wilkes (Gloucester).
Sunday
Sunderland (2) v Bradford (20)
Sunderland central defender Stanislav Varga is suspended after being sent off against Crystal Palace and his absence paves the way for the return of Jody Craddock. Chris Makin is expected to recover from a groin injury but Darren Williams may continue at right-back after deputising in Wednesday's replay win at Selhurst Park.
Bradford midfielder David Hopkin, out for four months with an ankle ligament injury, could be on the bench, with boss Jim Jefferies expected to stick with the team beaten 3-0 by Manchester United last Saturday. Gary Walsh keeps his place in goal despite his blunder for United's first goal, while transfer-listed duo Benito Carbone and Stan Collymore are missing.
Last season: Sunderland 0 Bradford 1, Bradford 0 Sunderland 4.
Last five league matches: Sunderland W W D W W, Bradford L L L W L.
Top scorers: Kevin Phillips (Sunderland) 14, Benito Carbone and Dean Windass (Bradford) 5.
Match odds: H 1/3; A 7/1; D 3/1.
Referee: M Halsey (Herts).
Odds supplied by William Hill
