Leeds seem on the brink of a place in the last 32 following their 4-1 romp at Elland Road two weeks ago.
Having visited 20 different countries on their past European adventures, it is the first time the club have played in Russia.
Leeds destroyed coach Yuri Syomin's side with their brand of ruthless, attacking football and know an early away goal will kill the game stone dead.
David O'Leary will be determined to rid his side of any complacency, as he is fully aware the tie is far from over.
To preserve his side's advantage, O'Leary could decide to play Michael Duberry in a three-man central defence as he is now fully fit following a 10-match lay-off with a thigh strain.