An injury-time goal by substitute Trond Soltvedt gave Southampton a sensational 2-1 League Cup win against Liverpool at The Dell last night.
The Norwegian struck with virtually the last kick of the game to leave Liverpool regretting a host of missed chances in the second half.
The worst offender was Michael Owen who had given Liverpool a first-half lead before Dean Richards levelled for the Saints following a mistake by Brad Friedel.
The biggest surprise of the night came at Stamford Bridge where an admittedly below strength Chelsea lost 1-0 to First Division Huddersfield with Kenny Irons grabbing the winner 13 minutes from time.
There was also late drama at Elland Road where a twice taken free-kick by Danny Mills pulled victory out of the fire for Leeds against Blackburn.
The result was cruel for Rovers in general and in particular for keeper John Filan who had frustrated Leeds with a string of fine saves.
But a Premiership side did come a cropper at Pride Park where Jim Smith Derby suffered another blow in a disappointing season when they lost 2-1 to Bolton.
Derby took a first-half lead through the unsettled Mikkel Beck before Mark Fish levelled on the stroke of half-time. The winner was scored by Michael Johansen two minutes from the end.
Problems are growing for Nottingham Forest boss David Platt after his side's 4-1 defeat at Sheffield Wednesday.
Sheffield Wednesday manager Danny Wilson believes his side has "thrown off their inhibitions" following a second successive goal romp. A delighted Wilson said: "It's nice to be scoring so many goals and it keeps our mini-run going.
"The first half was very scrappy and there wasn't much for the fans to shout about, but the goal right on the stroke of half-time I believe knocked the stuffing out of Forest.
"In the second half we then passed the ball around with much more urgency, creating more chances and taking them.
"Our confidence is now high for the game against Leeds. It's two good results in front of our home fans who've not had much to cheer this season.
"I believe we have now thrown off our inhibitions and hopefully we can follow this up with another good performance at Leeds."
Tottenham were also convincing winners - 3-1 against First Division Crewe at White Hart Lane. Oyvind Leonhardsen, David Ginola and Tim Sherwood were the Spurs scorers.
Second-half goals from Marc Keller and Frank Lampard earned West Ham boss Harry Redknapp a 2-0 win against his old club Bournemouth at Upton Park.
West Ham manager, Harry Redknapp praised his players for their performance in the match claiming that it was a no-win situation for them.
"It was difficult for us and it was one of those games that as a manager you hate.
"It was a no-win situation and I thought the lads played very well to make sure they won.
"In the end it was comfortable and I always felt it was in control."
Muzzy Izzet and Emile Heskey were on target for Leicester in a 20 win against Grimsby at Filbert Street.
However, Leicester boss Martin O'Neill, said afterwards: "We looked far from our best and did just enough to win the game. All we could have hoped for was a home draw in the next round.
"Frankly I expected Grimsby to come at us a bit more, we have watched them and they have been better than that.
"If they had equalised from that penalty it might have made it interesting. But Tim Flowers made a great save and that was the turning point. The second goal killed the game, and we weren't troubled after that."
Grimsby boss Alan Buckley said: "Goals change games and we could have maybe done something if we'd scored that penalty. Paul Groves is very upset, it's only the second he's missed in his career.
"But frankly we hadn't threatened them up until that point and we hardly deserved to be level. Leicester won at a canter, and I'm disappointed by the way we went about the game."
The lowest ever crowd at the Riverside - 8,843 - saw Juninho score Middlesbrough's only goal against Watford.
William Hill last night made Arsenal and Villa 5 to 1 joint favourites to win the cup and also offer 6 to 1 Leeds, 13 to 2 Middlesbrough, 8 to 1 Spurs and West Ham, 10 to 1 Leicester, 12 to 1 Sheffield Wednesday, 16 to 1 Huddersfield and Wimbledon.