Manager Alex Ferguson hopes to have top scorer Ruud van Nistelrooy available for the Old Trafford clash with Southampton tomorrow.
The Dutch striker has missed three United games after being troubled by a hamstring problem that also prevented him turning out for Holland in Austria last month.
Among a host of changes to the side that lost to Maccabi Haifa on Tuesday are the inclusion of David Beckham, Juan Veron, Ryan Giggs and French duo Fabien Barthez and Laurent Blanc.
Wes Brown is nearing a return after his ankle operation, while Roy Keane, still battling back to fitness following hip surgery, will start a five-match ban next week unless he makes an appeal by today's 5 p.m. deadline.