Two Indian soldiers and four members of a Pakistan-based militant group were killed following a gunbattle in India's revolt-racked Kashmir state.
Nine people were also injured in sporadic violence after weekly Friday prayers in Indian Kashmir.
A crowd of about 1,000 protestors emerged from Jamia Masjid - the main mosque in Indian Kashmir's summer capital Srinagar - shouting anti-US slogans and carrying pictures of millionaire Saudi dissident Osama bin Laden.
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Police fired tear gas and shot over the protestors' heads to disperse the crowd injuring six people, a police spokesman said.
Protests over US-led attacks on Afghanistan have turned violent in various cities in the Islamic world.
In the Pakistani city of Karachi protesters fired on police and two people were admitted to hospital with bullet wounds, hospital sources said.
Police said demonstrators had fired on them during running battles on the streets but it was not immediately clear who had been injured.
The clashes began in the western district of the city, where a witness saw the security forces firing tear gas at the protestors and repeated volleys of live ammunition into the air in a bid to control a stone-throwing crowd that initially numbered some 3,000 people.
As the numbers of demonstrators rose with people arriving from other parts of the city, it quickly became apparent the police could not control the situation and they withdrew from the area.
By late afternoon, an estimated 20,000 people had congregated. After regrouping, police returned to the area and clashes spread into the central district.
The fresh violence, which followed attacks on buildings and vehicles earlier in the day, erupted after Friday prayers in western Karachi, a part of the city dominated by Pashtuns, the main ethnic group in Afghanistan and the support base for the ruling Taliban.
The initial clashes took place outside a Kentucky Fried Chicken outlet which had been torched earlier in the day. A government building was also attacked and a bus and several other vehicles set ablaze in morning violence. Large crowds have also congregated in Quetta in the northern Pakistan, which was the scene of the worst anti-US rioting this week.
Pakistani authorities have warned Afghans refugees that if they are arrested during protests they will be deported. General Pervez Musharraf, Pakistan's president, has ordered a zero telerance policy on violent protest.
Indonesian police have fired water cannon when around 500 people staged protests and set fire to an effigy of US President, Mr George W. Bush, outside the US embassy in Jakarta.
Malaysian Prime Minister, Mr Mahathir Mohamad called for a halt in the air strikes on Afghanistan, while his police turned water cannon on 3,000 protesters outside the US embassy in Kuala Lumpur.
Pakistan's main religious groups have called for a nationwide strike next Monday to protest against the visit of US Secretary of State Mr Colin Powell to Islamabad.
"The nation will not tolerate his unclean feet on our clean land," said a joint statement issued this morning by a dozen heads of religious parties, who urged Pakistanis to keep their shops and offices closed to protest against the visit.
Mr Powell's visit would "add salt to the injuries of Pakistani Muslims", the statement said.
In the southeastern Iranian city of Zahedan, a crowd responding to an official call for nationwide rallies, attacked the Pakistani consulate, breaking the windows with stones, police said.
Palestinian authorities also feared clashes in the Gaza Strip, where two people were shot dead on Monday in an unprecedented battle between police and university students protesting the US strikes.
Authorities are also clamping down on media coverage of the protests.
A newspaper editor has been arrested and a TV show criticising a police crackdown on a rally has been taken off air.
The Palestinian Authority has tried to distance itself from Osama bin Laden and to suppress coverage of anti-US marches.
In other states the picture was less clear, although protests have been staged in recent days in Cairo, Baghdad and Muscat.
AFP