There have been 90 drug seizures and 18 arrests at the concert in Slane Castle.
The Garda said the number of arrests was higher than in previous years.
The concert came to an end at around 10 p.m. but traffic restrictions in the area remained in place until the early hours.
Today’s gig was headlined by Welsh posters Stereophonics, with support from The Charlatans, Nickelback, Counting Crows, Ocean Colour Scene, Doves and Irish band The Revs and over 50,000 fans packed into the venue.
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Last year over 200,000 people attended two concerts by U2 at the natural amphitheatre.