Damien Duff has not recovered from his knee injury in time to line out against Georgia in tonight's Euro 2004 qualifier at Lansdowne Road.
The Blackburn star suffered damage to the tendon behind his knee during the win over Albania on Saturday.
In all, Kerr has made three changes from the side that beat Albania.
Lee Carsley, who came on for Mark Kinsella at the weekend, starts on the right flank of a 4-4-2 formation thats sees Celtic's Colin Healy replace Kinsella in the middle of the park.
Up front, Gary Doherty will partner Tottenham clubmate Robbie Keane. David Connolly makes way.
Ireland: Given; Carr, Breen, Cunningham, O'Shea; Carsley, Holland, Healy, Kilbane, Doherty, Keane. Subs: Harte, Kinsella, Reid, McPhail, Colgan, Connolly, Lee.
Georgia: Lomaia, Khizaneishvili, Khizanishvili, Kaladze, Amisulashvili, Didava, Rekhviashvili, Burduli, Asatiani, Demetradze, Shota Arveladze. Subs: Gvaramadze, Daraselia, Siradze, Shashiashvili, Aleksidze, Akhalaia.
Referee: Eduardo Itturalde Gonzalez (Spain)