Livestock marts will re-open next week - over three months after they were closed as a result of the foot-and-mouth scare.
The permit system for the movement of cattle has also been eased though restrictions applying to sheep and pigs - including their sale at marts - remains in place.
The Department of Agriculture made the announcement today after a meeting of the expert group advising it on procedures to prevent the spread of the disease.
The Minister, Mr Joe Walsh, confirmed the permit regime is to be discontinued in respect of cattle movement to marts for slaughter, within holdings and for export.
However it will be retained for farm-to-farm movements and for movements to Northern Ireland.
In relation to sheep and pig movements, the Minister stressed existing regimes would be retained for the time being and would be reviewed in the light of the ongoing programme of testing.
The Irish Creamery Milk Suppliers Association (ICMSA) have welcomed the news describing it as a victory for common sense while recognising the restrictions were necessary.
"The reopening of livestock marts for cattle sales is a very welcome development and farmers should immediately make plans regarding testing, for example, on the basis that the marts will be fully operational as and from Monday next," ICMSA president Mr Pat O’Rourke said.
"We must now set about removing all unnecessary restrictions on trade", he added.
Mr Walsh urged continued vigilance in light of the ongoing problem of foot-and-mouth in Britain, and the need to maintain effective disinfectant measures.
The Department is to hold discussions with marts to ensure the necessary arrangements are in place in advance of the re-opening of marts on 18 June.