Munster gained revenge for last season's European Cup final defeat by Leicester when they knocked the back-to-back champions out of this season's competition with a 20-7 victory at the Euro kings Welford Road fortress.
The Tigers, looking for a third successive European crown were undone by a series of handling errors while normally reliable Leicester full-back Tim Stimpson missed a succession of kicks.
But many of their mistakes were due to relentless pressure from their visitors.
Munster's Ireland half-back pairing of Ronan O'Gara and Peter Stringer both scored second-half tries, their scores separated by a Leicester touchdown from wing Steve Booth.
Munster were just 3-0 up after a lone penalty from stand-off O'Gara.
He extended the lead with a 52nd minute kick to make it 6-0. But in a rare spell of sustained handling, Leicester eventually got on the scoreboard with the game's first try.
Ireland wing Geordan Murphy was missed by international team-mate and Munster centre Rob Henderson. The Leicester playmaker burst through the gap and his beautifully timed pass sent Booth in.
Stimpson at last found his range with the conversion and English champions Leicester were 7-6 up.
But any thoughts of a Munster slump were soon put to one side with a fine try seven minutes later when O'Gara stretched over the line after good work by the Munster back-row.
The outside-half converted his own score and in the 74th minute he was involved in a magnificent score that sealed Munster's victory.
Stringer, from a scrum, fed O'Gara. He in turn passed to Henderson who found centre Mike Mullins. From his pass Alan Quinlan surged forward and Stringer, who had initiated the move was on hand to score under the posts.
O'Gara converted and after wing Anthony Horgan had hauled down Leicester centre Leon Lloyd in sight of the Munster line in injury time the game was up for the Tigers.
For all the Ireland internationals in the Munster team who saw their chance of a Grand Slam ended by an all-conquering England Six Nations team led by Leicester captain Martin Johnson a fortnight ago in Dublin it was a sweet result.
Munster's victory means there are no English teams in the last four of Europe's premier club rugby union competition.
Instead the semi-finals, to be played on the weekend of April 26-27, will see two Irish-French clashes. Munster are away to Toulouse and Leinster face Perpignan.